St. Cloud or Saint Cloud is a city in the U.S. state of Minnesota and the largest population center in the state's central region. The population …St. Cloud or Saint Cloud is a city in the U.S. state of Minnesota and the largest population center in the state's central region. The population was 68,881 at the 2020 census, making it Minnesota's 12th-largest city. St. Cloud is the county seat of Stearns County and was named after the city of Saint-Cloud, France, which was named after the 6th-century French monk Clodoald.