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  1. Acetolactate decarboxylase catalyzes the conversion of both enantiomers of acetolactate to the (R)-enantiomer of acetoin, via a mechanism that has been shown to involve a prior rearrangement of the non-natural (R) -enantiomer substrate to the natural (S)-enantiomer.
    Author: Victoria A. Marlow, Dean Rea, Shabir Najmudin, Martin Wills, Vilmos Fülöp
    Publish Year: 2013

    Structure and Mechanism of Acetolactate Decarboxylase

    pubs.acs.org/doi/10.1021/cb400429h
    pubs.acs.org/doi/10.1021/cb400429h
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  2. People also ask
    What is the function of acetolactate decarboxylase?
    Its functions include avoiding acidification, participating in regulation of the NAD + /NADH ratio, and storing carbon. Acetolactate decarboxylase is a well-characterized anabolic enzyme involved with 3-hydroxy butanone (acetoin). It catalyzes conversion of the (R)- and (S)-enantiomers of acetolactate to generate the single product, (R)-acetoin.

    Structural and enzymatic characterization of acetolactate decarboxylase

    link.springer.com
    Which enzyme catalyzes the chemical reaction acetolactate decarboxylase?
    The enzyme acetolactate decarboxylase ( EC 4.1.1.5) catalyzes the chemical reaction Hence, this enzyme has one substrate, (S)-2-hydroxy-2-methyl-3-oxobutanoate, and two products, (R)-2-acetoin and CO 2. This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds.

    Acetolactate decarboxylase - Wikipedia

    en.wikipedia.org
    What is acetolactate decarboxylase (ALDC)?
    Acetolactate decarboxylase [EC 4.1.1.5] (ALDC) catalyzes the conversion of α-acetolactate (AL) (2-hydroxy-2-methyl-3-oxobutanoate) (Falsafi-Zadeh et al. 2012) to (R)-AC and carbon dioxide via decarboxylation in the catabolic glycolytic pathway (Dolin and Gunsalus 1951; Juni 1952) and exists in many bacteria (Goupil Feuillerat et al. 1997).

    Structural and enzymatic characterization of acetolactate decarboxylase

    link.springer.com
    Does acetolactate decarboxylase convert to chiral acetoin?
    We performed kinetic studies on acetolactate decarboxylase from Bacillus subtilis using circular dichroism, allowing the conversion of acetolactate to chiral acetoin for real-time tracking, yielding a Km value of 21 mM and a kcat value of 2.2 s −1.

    Structural and enzymatic characterization of acetolactate decarboxylase

    link.springer.com
    Does -acetolactate decarboxylate in aqueous solution?
    It is well known that α-acetolactate spontaneously decarboxylates in aqueous solution and forms acetoin or diacetyl depending on the absence or presence of oxygen, respectively. The process can be accelerated in acidic environments and proceeds faster at high temperature [10, 11].

    Efficient production of α-acetolactate by whole cell catalytic

    microbialcellfactories.biomedcentral.com
    How stable is -acetolactate?
    Stability of α-acetolactate at different temperatures (20 °C (squares), 30 °C (circles), 40 °C (triangles) and 50 °C (diamonds)) and in the presence of 500 mM pyruvate and 100 mM citrate at pH 5.5. α-Acetolactate decarboxylates to mainly form acetoin but also other side products

    Efficient production of α-acetolactate by whole cell catalytic

    microbialcellfactories.biomedcentral.com
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  3. Wikipedia
    https://en.wikipedia.org › wiki › Acetolactate_decarboxylase

    Acetolactate decarboxylase - Wikipedia

  4. Springer
    https://link.springer.com › article

    Structural and enzymatic characterization of acetolactate …

  5. Studies of Acetolactate Decarboxylase
    ScienceDirect
    Characterization of acetolactate decarboxylase of Streptococcus thermophilus and its stereoselectivity in decarboxylation of α-hydroxy-β-ketoacids
    Acetolactate decarboxylase (ALDC) is a well-characterized catabolic enzyme catalyzes the decarboxylation of (±)-acetolactate to produce a single product, (R)-acetoin. It can also convert other racemic α-hydroxy-β-ketoacids to corresponding α -hydroxyketones in R-configuration. In this work, we prepa...
    Published: 2022/05/01
    Cited By: 0
    Keywords: Acetolactat…
    PubMed
    Structural characterization of an acetolactate decarboxylase from Klebsiella pneumoniae
    Acetolactate decarboxylase (ALDC) is a well-characterized anabolic enzyme involved with 3-hydroxy butanone (acetoin), an important physiological metabolite excreted by microbes. Although the enzyme is widely present in microorganisms, few atomic structures and functions of ALDC have been reported to...
    Author: Wenyue Wu
    Published: 2019/01/29
    Keywords: Acetolactat…
    ResearchGate
    Structure and Mechanism of Acetolactate Decarboxylase
    Acetolactate decarboxylase catalyzes the conversion of both enantiomers of acetolactate to the (R)-enantiomer of acetoin, via a mechanism that has been shown to involve a prior rearrangement of the non-natural (R)-enantiomer substrate to the natural (S)-enantiomer. In this paper, a series of crystal...
    Author: Victoria A Marl…
    Published: 2013/08/28
    DOI: 10.1021/cb400429h
    PubMed
    Acetolactate Decarboxylase as an Important Regulator of Intracellular Acidification, Morphological Features, and Antagonism Properties in the Probiotic Lactobacillus reuteri
    Score: This study identifies the coding gene (aldB) of acetolactate decarboxylase (ALDC) as an important regulatory gene of the intracellular pH in Lactobacillus reuteri (L. reuteri), uncovering the important role of ALDC in regulating intracellular pH, morphological features, and antagonism propert...
    Author: Xueqing Wang
    Published: 2023 Dec
    Keywords: This study i…
    PubMed
    Structure and mechanism of acetolactate decarboxylase
    Acetolactate decarboxylase catalyzes the conversion of both enantiomers of acetolactate to the (R)-enantiomer of acetoin, via a mechanism that has been shown to involve a prior rearrangement of the non-natural (R)-enantiomer substrate to the natural (S)-enantiomer. In this paper, a series of crystal...
    Author: Victoria A Marl…
    Published: 2013/10/18
    Keywords: National In…
    ScienceDirect
    Structural characterization of an acetolactate decarboxylase from Klebsiella pneumoniae
    Acetolactate decarboxylase (ALDC) is a well-characterized anabolic enzyme involved with 3-hydroxy butanone (acetoin), an important physiological metabolite excreted by microbes. Although the enzyme is widely present in microorganisms, few atomic structures and functions of ALDC have been reported to...
    Published: 2019/01/29
    Cited By: 0
    Keywords: Acetolactat…
    PubMed
    Characterization of acetolactate decarboxylase of Streptococcus thermophilus and its stereoselectivity in decarboxylation of α-hydroxy-β-ketoacids
    Acetolactate decarboxylase (ALDC) is a well-characterized catabolic enzyme catalyzes the decarboxylation of (±)-acetolactate to produce a single product, (R)-acetoin. It can also convert other racemic α-hydroxy-β-ketoacids to corresponding α -hydroxyketones in R-configuration. In this work, we prepa...
    Author: Zi-Qi Zheng
    Published: 2022/5
    Keywords: Acetolactat…
  6. ScienceDirect
    https://www.sciencedirect.com › science › article › pii

    Characterization of acetolactate decarboxylase of Streptococcus ...

  7. RSC Publishing
    https://pubs.rsc.org › en › content › articl…

    Catalytic mechanism of acetolactate decarboxylase from

    Aug 16, 2016 · The conversion of (S)-α-acetolactate only contains two elementary steps: the direct decarboxylation of the substrate to form an enolate …

    • Author: Chenxiao Zhao, Hao Su, Yongjun Liu
    • Estimated Reading Time: 2 mins
    • Publish Year: 2016
  8. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Structural characterization of an acetolactate decarboxylase from ...

  9. Microbial Cell Factories
    https://microbialcellfactories.biomedcent…

    Efficient production of α-acetolactate by whole cell …

    Dec 29, 2019 · By expressing a robust α-acetolactate synthase (ALS) in a metabolically optimized Lactococcus lactis strain we obtained a whole-cell biocatalyst that efficiently converted pyruvate into α-acetolactate. After …

  10. ResearchGate
    https://www.researchgate.net › publication

    Structure and Mechanism of Acetolactate Decarboxylase

  11. BRENDA Enzyme Database
    https://www.brenda-enzymes.org › enzyme.php

    Information on EC 4.1.1.5 - acetolactate decarboxylase

  12. PubChem
    https://pubchem.ncbi.nlm.nih.gov › compound

    alpha-Acetolactate decarboxylase (enzyme preparation …

    alpha-Acetolactate decarboxylase (enzyme preparation from bacillus subtilis recombinant) | C21H25N3O3S | CID 1151802 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological …