- Studies of Estrogen Receptors in the Body
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See all on WikipediaEstrogen receptor - Wikipedia
Estrogen receptors (ERs) are proteins found in cells that function as receptors for the hormone estrogen (17β-estradiol). There are two main classes of ERs. The first includes the intracellular estrogen receptors, namely ERα and ERβ, which belong to the nuclear receptor family. The second class consists of … See more
In humans, the two forms of the estrogen receptor are encoded by different genes, ESR1 and ESR2 on the sixth and fourteenth chromosome (6q25.1 and 14q23.2), respectively. See more
Since estrogen is a steroidal hormone, it can readily diffuse through the phospholipid membranes of cells due to its lipophilic nature. As a result, estrogen receptors can be … See more
Cancer
Estrogen receptors are over-expressed in around 70% of breast cancer cases, referred to as " See moreEstrogen receptors were first identified by Elwood V. Jensen at the University of Chicago in 1958, for which Jensen was awarded the See more
Both ERs are widely expressed in different tissue types, however there are some notable differences in their expression patterns:
• The … See moreWikipedia text under CC-BY-SA license The Estrogen Receptors: An Overview from Different Perspectives
The estrogen receptors, ERα, ERβ, and GPER, mediate the effects of estrogenic compounds on their target tissues. Estrogen receptors are located in the tissues of the female reproductive …
- Author: Kathleen M. Eyster
- Publish Year: 2016
Estrogen: Hormone, Function, Levels & Imbalances - Cleveland Clinic
Feb 8, 2022 · Once it’s released, estrogen travels through the bloodstream until it reaches the part of your body that needs to be spurred into action. There, estrogen binds to a protein, called …
Estrogen Receptors: How Do They Signal and What Are Their Targets
In this review we focus on several of the interesting recent discoveries concerning estrogen receptors, on estrogen as a morphogen, and on the molecular mechanisms of anti-estrogen …
Estrogen receptors and their roles in the immune and …
Apr 15, 2021 · Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) are the major isoforms of estrogen that are highly specific in humans and enable selective hormonal actions in different tissues. This article reviews some of the …
Estrogen - StatPearls - NCBI Bookshelf
Jun 26, 2023 · Cellular physiological response to estrogen begins in the cell cytoplasm with estrogen binding to either alpha-estrogen receptor or beta-estrogen receptor. The activated …
Roles of Estrogen, Estrogen Receptors, and Estrogen-Related …
Jan 17, 2023 · Estrogen regulates the expression of its target genes by binding to its cognate receptors, estrogen receptors (ERs) α and β. Notably, the estrogen-related receptors …
Estrogen: A master regulator of bioenergetic systems in the brain …
Estrogen is a fundamental regulator of the metabolic system of the female brain and body. Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial function …
The many faces of estrogen signaling - PMC - National Center for ...
Oct 15, 2014 · Furthermore, there are several different mechanisms through which the three estrogen receptors (ERs), ERα, ERβ and G protein-coupled estrogen receptor 1 (GPER1) …
Role of estrogen receptors in health and disease
Three types of ERs, classical alpha (ERα) and beta (ERβ), as well as non-classical G protein-coupled estrogen receptor 1 (GPER1), are involved in several biological processes. In this review, we systematically illustrate the essential …
