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  1. Wikipedia
    https://en.wikipedia.org/wiki/Inhibitor_of_DNA-binding_protein

    Inhibitor of DNA-binding protein - Wikipedia

    • Inhibitor of DNA-binding/differentiation proteins, also known as ID proteins comprise a family of proteins that heterodimerize with basic helix-loop-helix (bHLH) transcription factors to inhibit DNA binding of bHLH proteins. ID proteins also contain the HLH-dimerization domain but lack the basic DNA-binding domain and thus regulate bHLH transcription fact… See more

    Function

    ID proteins are key regulators of development where they function to prevent premature differentiation of stem cells. … See more

    Subtypes

    Humans express four types of Id proteins (called ID1, ID2, ID3, and ID4).
    A recent publication in Cancer Research (August 2010) has shown that ID1 can be used to mark endothelial progenitor cells which are c… See more

    External links

    • Inhibitor+of+Differentiation+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more

    Inhibitor of DNA binding proteins: implications in human cancer ...
    National Center for Biotechnology Information
    The ID proteins: master regulators of cancer stem cells and ... - Nature
    Nature
    The Id-protein family in developmental and cancer-associ…
    Cell Communication and Signaling
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  1. ID proteins
    Inhibitor of DNA-binding/differentiation proteins, also known as ID proteins, are a family of proteins that heterodimerize with basic helix-loop-helix (bHLH) transcription factors to inhibit DNA binding of bHLH proteins1. ID proteins are small helix-loop-helix (HLH) proteins that lack a basic (b) DNA binding domain present in other family members, and function as dominant-negative regulators of other bHLH proteins (E proteins) by inhibiting their transcriptional activity2. During multiple stages of normal cardiogenesis, Id proteins play major roles in early development and participate in the differentiation and proliferation of cardiac progenitor cells and mature cardiomyocytes3.
    Learn more:
    Inhibitor of DNA-binding/differentiation proteins, also known as ID proteins comprise a family of proteins that heterodimerize with basic helix-loop-helix (bHLH) transcription factors to inhibit DNA binding of bHLH proteins.

    Inhibitor of DNA-binding protein - Wikip…

    en.wikipedia.org/wiki/Inhibitor_of_DNA-binding_pro…
    Inhibitor of DNA binding (ID) proteins are small helix-loop-helix (HLH) proteins that lack a basic (b) DNA binding domain present in other family members, and function as dominant-negative regulators of other bHLH proteins (E proteins) by inhibiting their transcriptional activity.

    Frontiers | Inhibitor of DNA binding prote…

    www.frontiersin.org/journals/immunology/articles/1…
    Id proteins, inhibitors of DNA binding, are transcription regulators containing a highly conserved helix-loop-helix domain. During multiple stages of normal cardiogenesis, Id proteins play major roles in early development and participate in the differentiation and proliferation of cardiac progenitor cells and mature cardiomyocytes.

    Inhibitor of DNA binding in heart develo…

    biosignaling.biomedcentral.com/articles/10.1186/s1…
  2. People also ask
    What is inhibitor of DNA binding?
    Am J Transl Res. 2018; 10 (12): 3887–3910. Published online 2018 Dec 15. Inhibitor of DNA binding (ID) proteins are a class of helix-loop-helix (HLH) transcription regulatory factors that act as dominant-negative antagonists of other basic HLH proteins through the formation of non-functional heterodimers.

    Inhibitor of DNA binding proteins: implications in human cancer progre…

    ncbi.nlm.nih.gov
    What are inhibitors of DNA binding and cell differentiation?
    Provided by the Springer Nature SharedIt content-sharing initiative Inhibitors of DNA binding and cell differentiation (Id) proteins are members of the large family of the helix-loop-helix (HLH) transcription factors, but they lack any DNA-binding motif.

    The Id-protein family in developmental and cancer-associated pathway…

    biosignaling.biomedcentral.com
    Do inhibitors of DNA binding proteins bridge the properties of cancer stem cells?
    The inhibitor of DNA binding (ID) proteins probably bridge the properties of normal and cancer stem cells better than any other family of proteins. In this Review, we summarize the most recent and somewhat tumultuous developments regarding the ID family in cancer.

    The ID proteins: master regulators of cancer stem cells and tumour aggr…

    nature.com
    Can chemical inhibitors be used to modulate DNA-binding activity of proteins?
    The repurposing of chemical inhibitors currently in use for modulating DNA-binding activity of proteins will have interesting implications in cancer research. The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

    An immunochemistry-based screen for chemical inhibitors of DNA-prot…

    bmccancer.biomedcentral.com
    Why do stem cells need an inhibitor of DNA binding?
    In embryonic stem cells, somatic stem cells and progenitors, inhibitor of DNA binding (ID) family members are required to preserve stem cell identity and prevent premature differentiation (Fig. 1).

    The ID proteins: master regulators of cancer stem cells and tumour aggr…

    nature.com
    What is chemical inhibition of DNA-binding?
    Unlike the above-mentioned techniques involving mutations (that is, stable and irreversible) or RNA interference (that is, slow and transitory), chemical inhibition of DNA-binding would allow rapid targeting of proteins such as transcription factors, chromatin modulators, and regulators of replication and DNA repair.

    An immunochemistry-based screen for chemical inhibitors of DNA-prot…

    bmccancer.biomedcentral.com
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  3. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325517

    Inhibitor of DNA binding proteins: implications in human cancer ...

  4. Nature
    https://www.nature.com/articles/nrc3638

    The ID proteins: master regulators of cancer stem cells and

  5. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211148

    Inhibitor of Differentiation 1 (Id1) in Cancer and Cancer Therapy

  6. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9389078

    Inhibitor of DNA binding proteins revealed as orchestrators of …

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  8. Nature
    https://www.nature.com/articles/s41388-022-02310-0

    Inhibitor of DNA binding 2 (ID2) regulates the expression of

  9. BMC Cancer
    https://bmccancer.biomedcentral.com/articles/10...

    An immunochemistry-based screen for chemical inhibitors of DNA …

  10. Cell Communication and Signaling
    https://biosignaling.biomedcentral.com/articles/10...

    The Id-protein family in developmental and cancer-associated …

  11. American Society of Hematology
    https://ashpublications.org/blood/article/132...

    Inhibitor of DNA Binding 2 (ID2) Plays a Key Tumor Suppressor …

  12. PubMed
    https://pubmed.ncbi.nlm.nih.gov/30662638

    Inhibitor of DNA binding proteins: implications in human cancer ...