About 97,600 results
Open links in new tab
  1. Cytosolic malate dehydrogenase
    Oxaloacetate is reduced to malate by cytosolic malate dehydrogenase in the cytosol, accompanied by the oxidation of cytosolic NADH to NAD+1234. The malate then crosses the mitochondrial membrane. Once in the mitochondria, malate is oxidized by NAD+ back to oxaloacetate forming NADH4. Oxaloacetate is transported back to the cytosol by the oxaloacetate/malate antiporter4. This process is needed to transport oxaloacetate out of the mitochondria234.
    Learn more:
    In the cytosol, oxaloacetate is reduced to malate by the cytosolic malate dehydrogenase, accompanied by the oxidation of cytosolic NADH to NAD+ (Figure 20.24). The malate then crosses the mitochondrial membrane.

    Oxaloacetate conversion from malate - Bi…

    chempedia.info/info/oxaloacetate_conversion_from…
    In order to get the oxaloacetate out of the mitochondria, malate dehydrogenase reduces it to malate, and it then traverses the inner mitochondrial membrane. Once in the cytosol, the malate is oxidized back to oxaloacetate by cytosolic malate dehydrogenase.

    Malate dehydrogenase - Wikipedia

    en.wikipedia.org/wiki/Malate_dehydrogenase
    NADH reduces oxaloacetate to malate. This transformation is needed to transport the molecule out of the mitochondria. Once in the cytosol, malate is oxidized to oxaloacetate again using NAD+. Then oxaloacetate remains in the cytosol, where the rest of reactions will take place.

    Oxaloacetic acid - Wikipedia

    en.wikipedia.org/wiki/Oxaloacetic_acid
    In the cytosol, oxaloacetate is reduced to malate by electrons from NADH. … Inside the mitochondrion, malate is oxidized by NAD+ back to oxaloacetate forming NADH. Oxaloacetate is transported back to the cytosol by the oxaloacetate/malate antiporter. In this way, NADH is transferred from cytosol into mitochondria.

    How does oxaloacetate reduce malate? - …

    studybuff.com/how-does-oxaloacetate-reduce-mala…
  2. People also ask
    How is oxaloacetate reduced?
    Oxaloacetate is reduced with nicotine adenine dinucleotide (NADH) to produce malate. Malate can be transported directly back into the mitochondrion, or it can undergo oxidative decarboxylation with malic enzyme. Oxidative decarboxylation of malate produces pyruvate, CO 2, and nicotinamide adenine dinucleotide phosphate (NADPH).

    Oxaloacetic Acid - an overview | ScienceDirect Topics

    sciencedirect.com
    How can one lower their oxalates?

    Cassia D Muller

    Bachelor in Nutrition · 2 years of exp

    Consuming calcium during meals with foods rich in oxalate, and controlling the amount of fat, this reduces its absorption. Restricting the oxalate content of the diet is also effective, and foods to be restricted are: oats, whole wheat, soy flour, strawberries, grapes, citrus fruits, plums, rhubarb, spinach, parsley, beetroot, chard, watercress, black tea, coffee instant, draft chocolate, cocoa powder, tofu, soy beans, peanut butter.
    Q&A: Food And Conditions
    bing.com
    How does malate trafficking affect oxaloacetate oxidation?
    The interconversion of malate and oxaloacetate mediated by malate dehydrogenases requires oxidation/reduction of NAD (P)H/NAD (P) +; therefore, malate trafficking serves to transport reducing equivalents and this is termed the ‘malate shuttle’. Although the term 'malate shuttle' was coined more than 50 years ago, novel functions are still emerging.

    Physiological functions of malate shuttles in plants and algae

    cell.com
    Which enzyme catalyzes the interconversion of malate to oxaloacetate?
    Malate dehydrogenases catalyzes the interconversion of malate to oxaloacetate. In the citric acid cycle, malate dehydrogenase is responsible for catalyzing the regeneration of oxaloacetate This reaction occurs through the oxidation of hydroxyl group on malate and reduction of NAD +.

    Malate dehydrogenase - Wikipedia

    en.wikipedia.org
    How is oxaloacetate catalyzed?
    Catalysis then proceeds by closing of a Ω–loop lid-domain, during which a stabilized enolate intermediate is formed after decarboxylation of oxaloacetate, allowing for phosphoryl transfer from the nucleotide, rather than the energetically more favourable protonation (Carlson and Holyoak 2009; Cui et al. 2017).

    PEP-pyruvate-oxaloacetate node: variation at the heart of metabolism | …

    academic.oup.com
    How does malate dehydrogenase convert oxaloacetate to aspartate?
    Malate is acted on by malate dehydrogenase to become oxaloacetate, producing a molecule of NADH. After that, oxaloacetate will be recycled to aspartate, as transaminases prefer these keto acids over the others. This recycling maintains the flow of nitrogen into the cell.

    Oxaloacetic acid - Wikipedia

    en.wikipedia.org
    Feedback
  3. See more
    See more
    See all on Wikipedia
    See more
    Wikipedia
    https://en.wikipedia.org/wiki/Oxaloacetic_acid

    Oxaloacetic acid - Wikipedia

    NADH reduces oxaloacetate to malate. This transformation is needed to transport the molecule out of the mitochondria. Once in the cytosol, malate is oxidized to oxaloacetate again using NAD+. Then oxaloacetate remains in the cytosol, where the rest of reactions will take place. See more

    Overview

    Oxaloacetic acid (also known as oxalacetic acid or OAA) is a crystalline organic compound with the chemical formula HO2CC(O)CH2CO2H. Oxaloacetic acid, in the form of its conjugate base oxaloacetate, is a See more

    Properties image
    Biosynthesis

    Oxaloacetate forms in several ways in nature. A principal route is upon oxidation of L-malate, catalyzed by malate dehydrogenase, … See more

    See also

    • Dioxosuccinic acid
    • Glycolysis
    • Oxidative phosphorylation
    • Citric acid cycle See more

    Biochemical functions image
    Overview image
    Properties

    Oxaloacetic acid undergoes successive deprotonations to give the dianion:
    HO2CC(O)CH2CO2H ⇌ O2CC(O)CH2CO2H + H , pKa = 2.22 O2CC(O)CH2CO2H … See more

    Biochemical functions

    Oxaloacetate is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalyzed by citrate synthase. … See more

    From Wikipedia
    From Wikipedia
    Content
    Overview
    Properties
    Biosynthesis
    Biochemical functions
    See also
    See all sections
    Wikipedia text under CC-BY-SA license
    Feedback
  4. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC11461317

    Catalytic mechanism and kinetics of malate dehydrogenase

  5. Studies of Oxaloacetate Reduced to Malate
    National Center for Biotechnology Information
    Functional Properties of the Mitochondrial Carrier System
    The mitochondrial carrier system (MCS) transports small molecules between mitochondria and the cytoplasm. It is integral to the core mitochondrial function to regulate cellular chemistry by metabolism. The mammalian MCS comprises the transporters of the 53 member canonical SLC25A family and a lesser...
    Author: Eric B. Taylor
    Published: 2017/09
    DOI: 10.1016/j.tcb.201…
    PubMed
    Malate dehydrogenases--structure and function
    Malate dehydrogenases (MDH, L-malate:NAD oxidoreductase, EC 1.1.1.37), catalyze the NAD/NADH-dependent interconversion of the substrates malate and oxaloacetate. This reaction plays a key part in the malate/aspartate shuttle across the mitochondrial membrane, and in the tricarboxylic acid cycle with...
    Author: P Minárik
    Published: 2002/9
    Keywords: National In…
    ResearchGate
    Oxaloacetate-to-malate conversion by mineral photoelectrochemistry: implications for the viability of the reductive tricarboxylic acid cycle in prebiotic chemistry
    The carboxylic acids produced by the reductive tricarboxylic acid (rTCA) cycle are possibly a biosynthetic core of initial life, although several steps such as the reductive kinetics of oxaloacetate (OAA) to malate (MA) are problematic by conventional chemical routes. In this context, we studied the...
    Published: 2008/09/05
    DOI: 10.1017/S147355…
    iubmb.onlinelibrary.wiley.com
    The malate–aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway
    This article presents a personal and critical review of the history of the malate–aspartate shuttle (MAS), starting in 1962 and ending in 2020. The MAS was initially proposed as a route for the oxidation of cytosolic NADH by the mitochondria in Ehrlich ascites cell tumor lacking other routes, and to...
    Author: Piet Borst
    Published: 11 Septem…
    Cited By: 97
  6. Biology LibreTexts
    https://bio.libretexts.org/Bookshelves/Biochemistry...

    13.3: Gluconeogenesis - Biology LibreTexts

    Tags:
    Malate dehydrogenase
    Gluconeogenesis
  7. Wikipedia
    https://en.wikipedia.org/wiki/Malate_dehydrogenase

    Malate dehydrogenase - Wikipedia

  8. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773108

    Functional Properties of the Mitochondrial Carrier System

    Tags:
    Malate dehydrogenase
    Eric B. Taylor
    Publish Year:2017
    Published:2017/09

  9. Images of oxaloacetate Reduced to malate

    bing.com/images
    See all images
  10. ScienceDirect
    https://www.sciencedirect.com/.../oxaloacetic-acid

    Oxaloacetic Acid - an overview | ScienceDirect Topics

    Tags:
    Carboxylation of Pyruvate
    Oxaloacetic Acid Is Also Known as
    PEPCK-C
  11. PubMed
    https://pubmed.ncbi.nlm.nih.gov/12537350

    Malate dehydrogenases--structure and function - PubMed

    Tags:
    Minárik P, Tomásková N, Kollárová M, Antalík M
    Publish Year:2002
  12. PubChem
    https://pubchem.ncbi.nlm.nih.gov/pathway/PlantCyc:ARA_PWY-7047

    malate-oxaloacetate shuttle I | Pathway - PubChem

  13. Oxford Academic
    https://academic.oup.com/femsre/article/…

    PEP-pyruvate-oxaloacetate node: variation at the heart …

    Dec 8, 2020 · Oxaloacetate is part of the tricarboxylic acid cycle, where it accepts acetyl-CoA or is reduced to malate. Oxaloacetate also functions as a precursor for aspartate, which in turn is used for the biosynthesis of many …

    Tags:
    Publish Year:2021
    PEP-pyruvate-oxaloacetate
    British Rail Classes 445 and 446
  14. Cell Press
    https://www.cell.com/trends/plant-science/f…

    Physiological functions of malate shuttles in plants and …

    Nov 27, 2021 · The interconversion of malate and oxaloacetate mediated by malate dehydrogenases requires oxidation/reduction of NAD (P)H/NAD (P) +; therefore, malate trafficking serves to transport reducing equivalents and this …

    Tags:
    Publish Year:2021
    Quasi-analytic function
  16. Some results have been removed