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  2. Thygeson Superficial Punctate Keratitis - EyeWiki

    • Described in 1950 by Phillips Thygeson in a case report series, Thygeson's superficial punctate keratitis (TSPK) is an insidious, chronic and recurrent disorder, characterized by small and elevated ov… See more

    Epidemiology

    There are no specific data on the epidemiology of the disease. TSPK may affect both sexes, but a higher incidence has been reported in females. The onset of the disease occurs between the second and third d… See more

    Pathophysiology

    The pathophysiology of TSPK remains unknown. Both, viral and immunologic mechanisms have been … See more

    Clinical Manifestations

    The disease is usually bilateral, but may be asymmetric. Patients frequently experience photophobia, tearing, burning, foreign body sensation, and irritation during exacerbations. Pain, and blurry vision are also comm… See more

    Pathology

    The histopathology of TSPK is characterized by intra and intercellular edema at the level of the corneal epithelium and involvement of the subepithelial nerve plexus, Bowman’s membrane, and the anterior str… See more

    Differential Diagnosis

    Based on the clinical course and the clinical manifestations of the disease, particularly the typical corneal lesions, the diagnosis of TSPK should not represent a problem. However, there are several clinical entities that may re… See more

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  1. Today, this condition is known as Thygeson superficial punctate keratitis (TSPK). It is a chronic, often bilateral, recurring illness, with relapses over years to decades. Multiple, whitish gray, intraepithelial corneal lesions, with minimal to no conjunctival involvement, are trademark characteristics of the disease.
    emedicine.medscape.com/article/1197335-overview
    Described in 1950 by Phillips Thygeson in a case report series, Thygeson's superficial punctate keratitis (TSPK) is an insidious, chronic and recurrent disorder, characterized by small and elevated oval corneal intraepithelial, whitish-gray opacities, extending to the entire anterior surface of the cornea of both eyes.
    eyewiki.org/Thygeson_Superficial_Punctate_Keratitis
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  3. Thygeson's superficial punctate keratopathy - Wikipedia

  4. Thygeson's Superficial Punctate Keratitis - University of …

    Apr 12, 2003 · TSPK tends to have a chronic recurrent course with asymptomatic periods during which both corneas are clear interrupted by episodes of blurred vision and minor eye irritation. One remarkable feature is the absence of any …

  5. Thygeson’s Disease/Superficial Punctate Keratitis

    Mar 30, 2019 · Learn more about Thygeson’s disease (more commonly known as punctate epithelial keratitis or superficial punctate keratitis), including the …

  6. Patient Diagnosis and Management of Thygeson’s Superficial …

  7. What Is Superficial Punctate Keratitis? - All About Vision

    Aug 30, 2022 · Thygeson superficial punctate keratitis (TSPK) is a rare disease named after Phillips Thygeson. He first described the condition in 1950. It is a chronic condition that causes the development of SPK and round-shaped gray …

  8. What Is Thygeson's Superficial Punctate Keratitis? | OBN

    Jan 17, 2023 · Thygeson's Keratitis, also known as Thygeson's Superficial Punctate Keratitis, is a rare inflammatory disorder of the cornea. It is characterized by the presence of small, superficial lesions on the surface of …

  9. What is punctate keratitis? - American Academy of …

    May 13, 2024 · Superficial punctate keratitis (SPK) is the characteristic finding in Thygeson's Disease where the upper layers of the cornea are inflamed. An ophthalmologist may see small white opacities just below the surface of the …

  10. Thygeson's superficial punctate keratitis

    Thygeson's superficial punctate keratitis is a potentially chronic condition, which might affect people of all ages for years to decades. Corticosteroids are the mainstay of treatment, with extended-wear contact lens and topical …